Abstract Colchicine is extracted from Colchicum autumnale (autumn crocus, or meadow saffron) and Gloriosa superba (glory lily). It is a lipid-soluble alkaloid that is isolated from the plant and is one of the main agents used in the treatment of crystal arthropathy gout, immune-mediated disorders such as Behçet’s disease (characterized by vasculitis), familial Mediterranean fever (characterized by polyserositis and amyloidosis), and neutrophilic dermatoses. Because colchicin